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Excessive ROS accumulation, mitochondrial DNA damage, and impaired mitophagy contribute to compromised oocyte and granulosa cell survival

When B12 levels are chronically low due to poor absorption, the effects can extend beyond fatigue and cognitive symptoms

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Since this study is performed in mouse kidney epithelial cells, it would be interesting to see whether these findings apply to different cell types or different tissues, or whether this is conversed across species

(c) Flow cytometry analysis using Click-iT Plus EdU Alexa Fluor 647 and FxCycle Violet staining of UCSD-AML1 or A549 cells treated with DMSO, 2.5 or 5 M MitoCKi for 16 h