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In addition to increasing miR-146a expression in OPCs, T4 remarkably also increased miR-146a expression in microglia and significantly inhibited secretion of pro-inflammatory mediators (Zhou et al., 2015), all of which may promote remyelination (Crockford, 2007)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 81.Montero-Moran G, Caviglia JM, McMahon D, Rothenberg A, Subramanian V, Xu Z, et al

A Phase 2 trial (Obesity Research, 2004) found 12 weeks of subcutaneous AOD-9604 produced statistically significant abdominal fat reduction versus placebo without altering fasting glucose or insulin levels