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Creation of this article was supported by the Operational Programme Integrated Infrastructure for the project: Integrative strategy in development of personalised medicine of selected malignant tumours and its impact on quality of life, IMTS: 313011V446, co-financed by the European Regional Development Fund and LISPER project (grant no

doi: 10.1016/j.mbplus.2019.03.002 160 MadsenDHBuggeTH