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Importantly, treatment with marmelosin at both doses demonstrated a significant attenuation of these pathological changes, encompassing a reduction in interstitial inflammation, amelioration of pancreatic follicle cell swelling and necrosis, and a notable improvement in the organization of islet architecture (Figure 10AD)

NAD+ is a coenzyme central to cellular energy metabolism, DNA repair, and mitochondrial function, with downstream antioxidant effects through sirtuins and PARP pathways

ROS are known to directly induce lipid peroxidation, thereby promoting the progression of ferroptosis 34,35

Our research results also have certain limitations