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Systemic administration of therapeutics also results in off-target effects, as only a small fraction of the administered dose crosses the BBB, with the remainder accumulating and affecting peripheral tissues 71,72

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Neuron 19 , 11751186 (1997)

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Novel drug delivery systems targeting oxidative stress in chronic obstructive pulmonary disease: a review

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Chemical structures of diterpenoids 20 and 21

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