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Epigenetic regulation is also imparted by post-translational modifications of histone proteins, the core constituents of nucleosomes, which confer first-order packing of DNA in chromatin

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These substances are theorised to enhance hepatic fat metabolism and support liver function

Longitudinal studies in spontaneously hypertensive stroke-prone have demonstrated that gut dysbiosis precedes the onset of hypertension and is marked by shifts in bacterial community structure and altered tryptophan-kynurenine metabolism, implicating microbial pathways in the early development of hypertension and related neurovascular complications (Shi et al., 2022)