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Analysis of adverse effects (OR = 0.03, 95% CI: 0.030.09) revealed comparable safety profiles, with reported events primarily consisting of gastrointestinal symptoms (abdominal pain, nausea, reflux, diarrhea, constipation, flatulence, and indigestion), neurological effects (headache and daytime drowsiness), and occasional hypersensitivity reactions or cold sores

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So the logic that people have waged is that drugs like metformin or compounds like berberine that reduce mTOR levels or impact the mTOR pathway in ways that lead to net decreases in mTOR-- the logic is that that could somehow increase lifespan