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Host-derived 5-HT, released into the gut lumen from enterochromaffin cells, provides luminal signaling that may influence microbial gene expression and community structurerepresenting a reverse direction of the 5-HT signaling axis described in sections 2.3 and 5.1

When these free radicals outnumber the body's natural regulatory mechanisms, they lead to oxidative stress

However, the mechanism of ferroptosis remains controversial

In those days, they produced only 5% dog food

Targeting this pathway, genetic silencing of PD-L1 has been shown to restore sorafenib-induced ferroptosis, inhibit glycolytic reprogramming, and reduce the stemness properties of LCSCs, providing a solid theoretical basis for PD-L1-targeted strategies and combination ICI therapy in HCC [279, 280]