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May support healthy aging by preserving metabolic function, maintaining muscle oxidative capacity, and promoting cellular resilience

Since no single T cell subset has been definitively correlated with protection, inducing a diverse CD4 + T cell response remains a key objective in TB vaccine development, supported by strong and consistent evidence of CD4 + T cell-mediated protection in both preclinical and clinical studies ( + T cell responses have been more variable, and clinical evaluations of TB vaccine candidates have shown that CD8+ T cell responses were relatively poorly induced when compared to CD4+ T cell responses ( The discovery of novel protective antigens is key to the development of candidate subunit vaccines aimed at improving BCG efficacy

These findings suggest that targeted inhibition of CD38 ecto-enzymatic activity could be a potential pharmacological approach for SSc fibrosis treatment

Mathew, P