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Future work should prioritize a standardized biomarker framework that resolves cell-type, spatial and temporal features of Trk signaling in human osteosarcoma and supports sex-stratified, puberty-aware analyses of neurotrophin, Trk and immune pathways

This will contribute to a comprehensive understanding of the NRF2 regulatory network and provide a theoretical foundation for developing novel therapeutic strategies

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Dou, S.-H., Cui, Y., Huang, S.-M., & Zhang, B

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