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Fifteen years ago, researchers showed that low doses of oral cyclobenzaprine (3-4 mg) at bedtime reduced the alpha-EEG and mildly improved fibromyalgia pain

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Furthermore, elevated levels of pro-inflammatory interferon (IFN-), tumor necrosis factor (TNF-), and granzyme B (produced by CD8 + T cells) increased the IFN- level in the adipose tissue of middle-aged mice [11]

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