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The pathophysiologic mechanisms underpinning S-AKI are complex, and recent studies have shown that acute tubular necrosis, oxidative stress (7), mitochondrial dysfunction, inflammatory responses (8), microvascular dysfunction (9), and ischemia are involved (Figure 1)

Choose Sterile Water if: You are going to reconstitute the vial and use the entire contents immediately in a single application

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Patients should be referred urgently if they have neurological symptoms, if the diagnosis is unclear, or if there is inadequate clinical response to treatment