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Studies highlight that vitamin B12, along with folate, is needed as a major determinant of one-carbon metabolism, which produces the compound called SAM-e ( S-adenosyl methionine)

For SARS-CoV-2 M pro we used our novel tetrapeptide QS1 fluorogenic substrate, that has a lower k cat /K M value (k cat /K M = 859 s 1 M 1 ) in comparison to FRET substrates 22

Apart from improved TQ delivery through the oral route, further development should, therefore, focus on reduced hydrophobicity, thermal instability, and slower degradation of TQ

Cysteine is toxic to fungi in high concentrations similar to HICA and was included as a comparator

Early identification and treatment are important for preventing long-term complications and supporting overall health and daily functioning