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Key takeaways Master regulator of cell fate, proliferation and differentiation Central pathway in embryogenesis and adult tissue homeostasis Frequently dysregulated in cancer and fibrosis Strongly linked to stem cell maintenance and metabolic regulation Highly suitable for biomarker discovery and gene expression profiling Dynamic regulation of Wnt/-catenin signaling The pathway operates through a tightly regulated ON / OFF switch : OFF state -catenin is continuously phosphorylated and degraded by the destruction complex, preventing transcriptional activation

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This shift means hair follicles spend more time dormant and less time actively producing new hair strands