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Ruggeri RM, Trimarchi F, Giuffrida G, et al

"Altered NMDA glutamate receptor antagonist response in individuals with a family vulnerability to alcoholism"

10.1126/sciadv.abb3063 224 XueQ.YanD.ChenX.LiX.KangR.KlionskyD

PCOS is characterized by insulin resistance in many (though not all) patients the body's cells don't respond normally to insulin, leading to compensatory hyperinsulinemia (high circulating insulin), which in turn drives excess ovarian androgen production (testosterone and DHEA), disrupts follicular development, and impairs ovulation

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