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But, Stage B2 does not distinguish between mild MR and severe MR

Rh4 attenuated ROS production and normalized 8-OHdG and MDA levels in CUMS mice [57], while Rk1 stabilized MDA and SOD levels in LPS-exposed brains, thereby preventing depression-like phenotypes [108]

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By managing the silence of transposable elements and regulating gene expression, piRNAs play a critical role in protecting the germline in mammalian oocytes and early embryonic stages, maintaining genomic integrity and guaranteeing appropriate developmental progression [551, 552]