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Biodisponibilit orale: Stimata al 5-15% nei roditori secondo i modelli pubblicati significativamente pi elevata rispetto alla maggior parte dei peptidi orali, ma inferiore alla somministrazione parenterale

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4.2.3 Dual-substrate-competitive inhibitors Dual-substrate-competitive inhibitors compete with the both substrates (SAM and NAM) for the binding sites in NNMT, thereby increasing inhibitors activity and selectivity (Gao et al., 2021)