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Similarly, oral administration of either glutathione or other low-molecular-weight thiols (eg, 2-mercaptopropionylglycine or N-acetyl cysteine) to these patients neither substantially raises intracellular glutathione levels nor alters their acid-base balance or excretion of 5-oxoproline (71

At present, the separation technology of antioxidant collagen hydrolysates in biomedical domains mainly include chromatography, membrane separation, and combinations of these technologies

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Acknowledgements We are grateful to the animal facility staff at Beth Israel Deaconess Medical Center (BIDMC) for assistance with in vivo experimentation