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These results confirm the fact that in AD, as in certain other diseases the balance between ATP formation and ion pumping may be disordered resulting in a decrease in intercellular energy charge, and an increase in lactate formation and catabolism of adenylates (Ronquist and Waldenstrm, 2003)

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Another in vivo study also demonstrated ultra-structural defects in mitochondria of intestinal cells such as swollen and degenerated mitochondria with disintegrated cristae after 5-FU administration (Gawish et al

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1 Several of these have shown promising results and are being tested in phase 3 clinical trials (224)

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