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We conclude that a substantial investment in understanding the fundamental biology of NAD + , its detection and its metabolites in specific cells and cellular compartments is needed to support current translational efforts to safely boost NAD + levels in humans

Blokhina and Fagerstedt, Arabidopsis lacking a functional AOX is sensitive to drought stress and has altered transcription profiles of different components of the antioxidant machinery (Ho et al., Peroxisomes Peroxisomes are single-membrane-bound spherical microbodies and are the major sites of intracellular H 2 O 2 production due to their integral oxidative metabolism (Luis et al., 2009)

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