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In HFD-fed mice, the treatment demonstrated improvements in glucose tolerance, reduced hepatic steatosis, and alleviated adipose inflammation, partially by restoring oxidative stress, inflammation, and ERSrelated gene expression through SIRT1 (Yoshino et al

Methionine, an essential amino acid, is first converted to S-adenosylmethionine (SAM) by an ATP-dependent reaction

Methods: The study sample comprised 993 adults (Females 68%)

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