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Such conditions may further aggravate the underlying symptoms of senile cataract through the specific mechanisms of oxidative damage, abnormal migration of lens epithelial cell, elevated calcium or deficiency of glutathione

The PI3K/AKT/mTOR pathway is activated by CD147 to up-regulate HIF-1-mediated glycolysis, and CD147 inhibits PPAR-mediated FAO by activating the MAPK pathway, which eventually leads to drug resistance in cancer cells [86]

Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis

Further, Wenyu Huang and colleagues identified a causal association linking T2DM with altered lipid profiles, specifically lower HDL-C levels and elevated LDL-C and TG levels (257)

Major depression is also associated with chronic illnesses and reduced life expectancy, as are neurodegenerative diseases such as Alzheimers and Parkinsons