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It is important to note that flavonoids can exhibit both antioxidant and pro-oxidant properties, and their behavior may be influenced by factors such as test conditions, effective concentration at the site of ROS formation, stability of the flavonoid radical formed during hydrogen atom donation, lipophilicity for membrane absorption, and pH of the medium

doi: 10.1016/j.fsi.2013.05.006 135 LinT.ZhaiY.TianC.JiangD.ShiH.JiangM.et al

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When external factors lead to the deficiency of growth factors, steroid hormones, or the binding of death receptors, or when intrinsic factors cause DNA damage, caspases are activated