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Brain-First versus Gut-First Parkinsons Disease: A Hypothesis

Therefore, while the preclinical foundation for exploring anti-cytokine therapies exists, significant work is required to bridge this to clinical application, including identifying which tinnitus patients exhibit a dominant cytokine-driven pathology that would be amenable to such targeted biologics see in Figure 2 and

Song et al showed that decreasing periplasmic GSH by deleting the GSH exporter CydD triggers the CpxR/SoxS two-component systems, upregulating the AcrAB-TolC pump and lowering intracellular drug accumulation

Nucleic Acids Res 44:733745

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