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These naturally occurring substances are responsible for a variety of different processes in the body, including telling cells when to grow, repairing tissue, releasing hormones, and fighting infection

However, certain special situations, such as immature blood-brain barrier (BBB) in infants, compromised BBB, high-dose exposure, small molecular weight, few aromatic amino acids, light hydrophobicity, light cationic properties, transport mechanisms, and indirect effects, can affect BBB transitions (Domenger et al