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This may have important clinical considerations given that FHd-RCC is managed as a non-clear cell RCC under the European Society for Molecular Oncology (ESMO) guidelines, which recommend first-line antiangiogenic therapy 4

End stage renal disease (ESRD) with loss of kidney function results in renal replacement therapy with the need for dialysis or renal transplantation [29]

Excitingly, this is the target and basis for the pro-oxidant anti-tumor effects of Pt nanozymes

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In addition, these reactive metabolites can bind to proteins, lipids, or nucleic acids and inhibit the enzymes in the mitochondrial ETC, resulting in oxidative stress, mitochondrial dysfunction, and hepatotoxicity [310, 311]