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doi: 10.1007/s00705-006-0880-2 78 ZechmannB

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We hypothesized that this antagonism could be mediated by the multidrug resistance protein 1 (MRP1, encoded by ABCC1 ), a membrane transporter protein of the ATP-binding cassette (ABC) transporter superfamily that is involved in the cellular efflux of multiple compounds, including chemotherapeutic agents 54

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We further confirmed that RSL3 and TST significantly inhibited the clonogenesis of pancreatic cancer cells and that Fer-1 rescued this inhibition (Fig