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doi: 10.1136/ard-2022-223035 13 Bukulmez HGK

4.2.3 Targeting lactylation modification sites In contrast to the aforementioned strategies that indirectly modulate lactylation levels by regulating enzyme activity, a more precise interventional approach involves directly targeting the lactylation modification sites themselves, either by recognizing or blocking pathogenic modification events with specific antibodies, including pan-specific antibodies (anti-pan-Kla) that can identify lactic acid lysine residues in all proteins, and multi-site specific antibodies, such as anti-H3K18la, anti-H3K14la and anti-XRCC1 K247la

While women are often introduced to preventive healthcare through reproductive health visits, pregnancy care, and routine screening programs, men frequently lack comparable touchpoints

Cooking tomatoes increases the bioavailability of lycopene, so incorporating cooked tomato-based dishes into the diet enhances its skin-protective benefits