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As these pathways are important for Mtb virulence and to prevent the buildup of potentially toxic metabolites, it is vital to Mtb that these pathways are rigorously regulated

Store 5-Amino-1MQ as a lyophilized powder at -4F (-20C) in a tightly sealed vial, protected from light and moisture until required for laboratory research

These processes seem to have been regulated by epigenetic mechanisms, such as changes in chromatin status, gene silencing by miRNAs and alternative splicing reduction, which favored the reduction of gene transcription and translation