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In AD, level of Tau methylation at K254 exceeds its ubiquitination level in PHFs, hampering the clearance of Tau aggregates by ubiquitin proteasomal system (UPS) [25]

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Hyperglycemia-induced PKC activation also results in increased platelet derived growth factor receptor expression on smooth muscle cells and other vascular wall cells increased expression of TGF-P is thought to lead to thickening of capillary basement membrane, one of the early structural abnormalities observed in almost all tissues in diabetes (Gould and Newton, 2008)

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