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Emodin treatment of papillary thyroid cancer cell lines in vitro inhibits proliferation and enhances apoptosis via downregulation of NF-B and its upstream TLR4 signaling

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Different mechanisms have been reported for anti-inflammatory activity of melatonin including prevention of the activation of cyclooxygenase-2 and inducible isoform of nitric oxide synthase, as well as blocking of the transcriptional factorsthat stimulates pro-inflammatory cytokines production [167,168]