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Brum, V

Considering that IGF1Rs presence in the cell nucleus causes subcutaneous tumors to develop earlier and to reach larger volumes in addition to making them sensitive to the target therapy, it is possible that the receptor plays essential roles in the nucleus, directly or indirectly stimulating the expression of genes related to the observed phenotype

Vehicle control (distilled water), NAC (1 mM) or GSH (100 M) was added to cells for 7 days

NETs can promote apoptosis in cardiomyocytes via the autophagy pathway, and cause swelling of mitochondria in cardiomyocytes, depolarization of mitochondrial membrane potential, and increased production of mitochondrial ROS (153), resulting in an increased susceptibility to AF (152)