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Through a conserved cytoplasmatic domain, NL2 binds gephyrin (Poulopoulos et al., 2009) while an extracelullar motif mediates NL2 trans-synaptic interaction with presynaptic Neurexins (NRXs) boosting inhibitory presynaptic axonal differentiation during development (Chih et al., 2005)

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In cases when the redness is not severe and it fades after a short period of time, then there is no need to stop