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This somewhat contradicts the findings that, e.g., nhr-49 mutants, nhr-49 ( RNAi ), or fat-7 ( RNAi ) worms are short-lived, as these worms show changes in stearic to oleic acid ratio, but only relatively minor changes in the distribution of other fatty acid species, including most PUFAs (Van Gilst et al., 2005b)

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Resmetirom significantly reduced hepatic fat by 32.9% and 37.3% at 12 weeks and 36 weeks, respectively, compared with 10.4% and 8.5% in the placebo group

10.1016/j.jsxm.2019.06.010 108 WynnT