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Declaration of patient consent The authors certify that they have obtained written informed consent from all the patients

E., & Maenhaut, C

The management of GBM is hampered by several challenges, including tumour heterogeneity, the presence of therapy-resistant glioma stem cells, the highly infiltrative growth pattern of tumour, primary and acquired drug resistance, and BBB, which restricts drug delivery 7,8,27,28,29

however, recent findings indicate that amyloid formation in vivo may be promoted by disulfide bond formation between TTR subunits, suggesting oxidative stress as a potential contributor to protein misfolding and disease progression

Mamidala MP, Kalikiri MK, Praveen Kumar PT et al (2015) Consanguinity in India and its association with autism spectrum disorder