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There were only four downregulated genes in the MYO-2, and three of those DEGs are closely related to the cellular bioenergetics and stress defense: Prdx1 (peroxiredoxin-1) and Txnrd1 (thioredoxin reductase 1) are the members of antioxidant system and have reductase activity on ROS 47,48

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This dual approach to sustainable and lifelong health is in line with contemporary views on human physiology and health (173175), which requires a systemic perspective that integrates multimodal data from various entities to create a network functioning in health and disease and to explore its dynamic responses to disturbances (176)

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