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There is a research finding that ISL alleviated NAFLD through modulating miR-138-5p/PGC-1-mediated lipid metabolism and inflammatory reaction in vivo and in vitro (Wang et al., 2022b)

Biochim Biophys Acta 1969;192:560562

The synthetic analog replicates a 15-amino acid sequence and has been studied for its potential to influence fibroblast activity, angiogenesis, nitric oxide pathway regulation, and extracellular matrix remodeling across experimental models