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These in vivo findings not only reinforce the causal role of the MAGI3--catenin axis in driving everolimus resistance but also provide compelling preclinical evidence that dual-pathway blockade is a viable and well-tolerated strategy to overcome this resistance

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This concurs with studies describing that excess body weight may induce the over-production of sex hormones through a complex meshwork of interrelated mechanisms, such as secretion of the gonadotropin-releasing hormone, expression of the adrenocorticotropic hormone, and reduction of sex hormone-binding globulin levels [31]

Further, a specific correlation was observed between higher serum levels of B12, folate and homocysteine levels in the zinc group (Vasquez-Lorente et al., 2022)

Physiologically, the concentration of myo-inositol is several times higher than D-chiro-inositol in most tissues