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10.1016/j.jsps.2020.08.016 129 RajkumarK.MvsS.KogantiS.BurgulaS

J.YingS.HoltM

Despite the presence of this specific detoxification system, there is little empirical evidence that natural products are similarly S -glutathionylated and processed

Although there are some more bioavailable forms (like liposomal or acetylated glutathione), they tend to besignificantly more expensive

This targeted approach, selecting drugs to precisely disrupt key nodes like GPX4 within the ferroptosis pathway, is a cornerstone of current therapeutic strategies against GBM