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After incubation for 1 h at room temperature, the incubated sample was analyzed

Given that mitochondria are essential for tumorigenesis and cancer cell proliferation (3133), targeting the mitochondrial OXPHOS metabolic pathway may be a viable approach for inhibiting the growth of cancer cells (34)

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Although identified as a principal culprit driving immune evasion in these CRCs, 2M mutations are, perhaps counterintuitively, associated with favorable outcomes, such as reduced metastases and relapse, as they are protected against the formation of distant organ metastases in patients with MMR-deficient CRCs, particularly in LS [42, 77, 7981]

Funding This work received support from the Consejo Nacional de Ciencia y Tecnologa (CONACYT) FOSEC SEP-INVESTIGACIN BSICA A1-S-26479, and the International Society for Neurochemistry-CATEGORY 1C: Return Home grant to AME-S