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High-mobility group box 1 (HMGB1), released from damaged cells, binds to Toll-like receptor 4 (TLR4) on macrophages, triggering NF-B activation and production of pro-inflammatory cytokines such as IL-1 and TNF- (98)

& Ashenhurst, J

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[2] However, once stores are depleted, symptoms can include fatigue, weakness, constipation, loss of appetite, and neurological changes such as numbness, tingling, balance problems, and cognitive difficulties