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The fact that these nanoparticles specifically induce oxidative stress and apoptosis in irradiated cancer cells is explained by the suppression of their intrinsic catalase-like activity that happens in acidic conditions, at a pH of 4.3

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The lack of this basic residue in ROXY9 might add to its poor scaffold site either through its effect on the position of the loop or on other interactions within the thioredoxin fold