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doi: 10.2337/DB23-0307 96 BrownMEThirawatananondPPetersLDKernEJVijaySSachsLKet al

403 The CpG motif is prevalent in bacteria, and the CpG motif also recognizes plasmacytoid dendritic cells (pDC) expressing TLR9 that produce pro-inflammatory cytokines, induce Th1-like immune activation patterns and activate their migration, while CpG-A oligodeoxynucleotides (ODN) induces extremely high levels of IFN- production and CpG-B ODN induces activation of murine bone marrow-derived DCs to secrete IL-12 and IL-6