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The ferroptosis inducers include inhibitors targeting system Xc - (sorafenib) [55] and GPX4 (RSL3) [56], with ability to induce the accumulation of lipid peroxides [57], and directly suppressing GCL (L-buthionine sulfoximine, BSO) leading to GSH depletion [58]

A comprehensive approach involving evidence-based pharmacological treatments to improve bone mineral density, along with multidisciplinary strategies for fragility fracture prevention and management, would likely yield the most beneficial outcomes for elderly patients with osteoporosis [140, 141]

Hypermutation in human cancer genomes: footprints and mechanisms

Zhang Y, Yuan S, Pu J, Yang L, Zhou X, Liu L, et al