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Cellular adaptation mediated through Nrf2-induced glutamate cysteine ligase up-regulation against oxidative stress caused by iron overload in beta-thalassemia/HbE patients

Age-related macular degeneration (AMD) is one of the most common eye conditions for older adults

To address the ROS burst driven by ferroptosis and the imbalance of iron homeostasis, a study has developed a macrophage-targeting polysaccharide iron nanoenzyme, which possesses dual enzyme activities resembling catalase and peroxidase, capable of scavenging ROS, inhibiting lipid peroxidation, and controllably releasing Fe 2 to correct systemic iron deficiency [150]

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K.SaharanS.TripathiM.MurariG