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The BAC-concentrating effect is most meaningful during more significant fluid loss from heat, altitude, intense exercise, or illness not from skipping one glass of water

10.1038/sj.embor.embor918

LC3 recruitment is inhibited in the Atg7 knockout mouse model, LAMP2 expression is lower, autolysosome formation is impaired, sperm cytoplasmic clearance and mitochondrial rearrangement are inhibited, and PDLIM1 accumulates owing to impaired clearance, disrupting the assembly of sperm flagella and resulting in blocked sperm formation, reduced sperm motility, and asthenospermia [60, 146]

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For example, ALS presents both sporadic and familial forms, often linked to defective DNA repair, which leads to neuronal damage, premature aging, and subsequent neurodegeneration ( 2.5 Ferroptosis in neurodegenerative pathogenesis Iron is the most abundant transition metal in the human brain and participates in vital CNS functions such as mitochondrial energy transduction, enzymatic catalysis, myelination, synaptic plasticity, and neurotransmitter synthesis and degradation ( Figure 1