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For HIF transcription factors, this occurs by hydroxylation at conserved proline residues by prolyl hydroxylases under normoxia, allowing their recognition and ubiquitination by the VHL E3 ubiquitin ligase, which targets HIFs for proteasomal degradation

With a PhD in nutritional sciences and years of research in mitochondrial biology, his work focuses on translating peer-reviewed science into practical tools for human health

Cancer Chemother Pharmacol 35:377386 Li L, Elkholy W, Rhodes CJ, Brubaker PL (2005) Glucagon- like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B

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