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doi: 10.3233/JAD-200136 348 TraxlerL.HerdyJ

Lipid metabolism Increased oxidation and decreased synthesis of fatty acid In addition to glucose and amino acids, cancer cells also utilize fatty acids (acquired from the extracellular matrix or from de novo synthesis) as an alternative energy source through fatty acid oxidation (FAO), which is a very efficient way to produce energy

Formation of oxygen radicals in biological systems There are many and various types of free radicals in biological systems, however, those derived from oxygen, generally termed reactive oxygen species (ROS) are of major concern and interest to researchers in the field of free radical chemistry

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Poor candidates better served by standard care Advanced disease: Severe vision loss from end-stage glaucoma, geographic atrophy, or proliferative diabetic retinopathy