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Mitochondrial myopathies: disorders of the respiratory chain and oxidative phosphorylation

The main selenoprotein families are GPXs that include (i) five Se-dependent members and other non-Se-dependent GPX isoenzymes, which have oxidoreductase functions and also regulate the immune response

And it gets worse

IGF-1R is also known to bind the Wnt-signaling associated transcription factor LEF-1 [123], and upregulate TCF-mediated transcriptional activity of -catenin [123, 125]