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Physiol Rev 90(1):207258 Marin-Garcia J, Goldenthal MJ (2002) Fatty acid metabolism in cardiac failure: biochemical, genetic and cellular analysis

Additionally, chronic estradiol application promotes the expression of interleukin (IL)1, IL-6, IL-12p40, and Inducible nitric oxide synthase (iNOS) in macrophages following lipopolysaccharide (LPS) stimulation, further enhancing immune responses [105]

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This transcriptional program activates a broad array of genes involved in angiogenesis (e.g., VEGF, ANGPT1), glycolytic metabolism (e.g., GLUT1, PDK1), survival (e.g., BNIP3), and matrix remodeling (e.g., MMPs, TIMPs) (Zhang et al., 2025

Regulators allow canthaxanthin in small amounts as a food colour, but not at the huge doses used in tanning pills, because it has been linked with problems such as yellow deposits in the retina and vision changes